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manganeseenhanced magnetic resonance imaging memri springer

Development of a dendritic manganese-enhanced magnetic resonance

A new dendritic manganese(II) chelate 1 has been evaluated by in vivo (relaxivity) and in vitro (toxicity and relaxivity) experiments as a manganese enhanced magnetic resonance imaging (MEMRI) contrast agent. Also, a comparison with its corresponding gadolinium(III) homologue 2 and the commercially …

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Manganese-enhanced magnetic resonance imaging (MEMRI …

Manganese-enhanced MRI (MEMRI) is being increasingly used for MRI in animals due to the unique T1 contrast that is sensitive to a number of biological processes. Three specific uses of MEMRI have been demonstrated: to visualize activity in the brain and the heart; to trace neuronal specific connecti …

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Mapping of the mouse olfactory system with manganese …

Springer-Verlag 2012 Abstract As the power of studying mouse genetics and behavior advances, research tools to examine systems level connectivity in the mouse are critically needed. In this study, we compared statistical mapping of the olfactory system in adult mice using manganese-enhanced MRI (MEMRI) and diffusion tensor imaging (DTI) with prob-

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Manganese-enhanced magnetic resonance imaging (MEMRI)

Manganese-enhanced MRI (MEMRI) evolved in the late nineties when Koretsky and associates pioneered the use of MEMRI for brain activity measurements (2) as well as …

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Altered transition metal homeostasis in mice following

In manganese-enhanced magnetic resonance imaging (MEMRI), the paramagnetic divalent ion of manganese (Mn2+) is injected into animals to generate tissue contrast, typically at much higher exposures than have been previously used in studies of Mn toxicity. Here we investigate the effect of these injections on the homeostasis of the …

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Manganese-enhanced magnetic resonance imaging (MEMRI)

The use of manganese ions (Mn(2+)) as an MRI contrast agent was introduced over 20 years ago in studies of Mn(2+) toxicity in anesthetized rats (1). Manganese-enhanced MRI (MEMRI) evolved in the late nineties when Koretsky and associates pioneered the use of MEMRI for brain activity measurements (2) …

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Manganese-enhanced magnetic resonance imaging …

Manganese-enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations Afonso C. Silva,1* Jung Hee Lee,1 Ichio Aoki2 and Alan P. Koretsky1 1Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, Bethesda, MD, USA

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Manganese-Enhanced Magnetic Resonance Imaging

Manganese-enhanced magnetic resonance imaging (MEMRI) relies on contrasts that are due to the shortening of the T1 relaxation time of tissue water protons that become …

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Manganese-Enhanced Magnetic Resonance Imaging Reflects …

To this end, we now report that manganese (Mn 2+)-enhanced magnetic resonance imaging (MEMRI) can reflect brain region-specific HIV-1-induced …

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Manganese-enhanced magnetic resonance imaging (MEMRI…

The MEMRI neuronal activity studies have been generally performed either by stereotactic brain injection or by systemic administration of Mn(2+) in conjunction with t … Manganese-enhanced magnetic resonance imaging (MEMRI) without compromise of the blood-brain barrier detects hypothalamic neuronal activity in vivo

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Semiquantitative assessment of optic nerve injury using

MEMRI protocols and data analysis. The MRI was performed on days 3, 7, and 14 post optic nerve crush on group II (n = 5 on each day, totaling 15).MnCl 2 aqueous solution was injected into the vitreous body of the eye 24 h prior to the MR imaging. Anesthetized animals were placed on a disinfected table and 3 µL of a 30 mM MnCl 2 …

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Manganese-Enhanced Magnetic Resonance Imaging: …

Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system …

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Manganese-Enhanced Magnetic Resonance Imaging (MEMRI)

Manganese-enhanced MRI (MEMRI) evolved in the late nineties when Koretsky and associates pioneered the use of MEMRI for brain activity measurements (2) as well as neuronal tract tracing (3).

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Manganese-enhanced magnetic resonance imaging (MEMRI)

This special issue of NMR in Biomedicine on manganese-enhanced MRI (MEMRI) is aimed at providing the readers of this journal with an extensive review of …

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Manganese-Enhanced Magnetic Resonance Imaging

Manganese-enhanced magnetic resonance imaging (MEMRI) relies on contrasts that are due to the shortening of the T 1 relaxation time of tissue water protons …

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Studying Axonal Transport in the Brain by Manganese-Enhanced Magnetic

Studying Axonal Transport in the Brain by Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) Methods Mol Biol. 2022:2431:111-142. doi: 10.1007/978-1-0716-1990-2_6. ... LLC, part of Springer Nature. Publication types Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't MeSH terms Animals

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Repeatability and reproducibility of cardiac manganese-enhanced

Cardiac magnetic resonance imaging has a major role in the diagnosis, evaluation of myocardial function and tissue characterization of a range of cardiovascular diseases 1,2,3.Conventional cardiac ...

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In Vivo Tracking of Transplanted Mononuclear Cells Using …

In Vivo Tracking of Transplanted Mononuclear Cells Using Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) Kenichi Odaka, 1 Ichio Aoki, 1, * Junji Moriya, 2 Kaoru Tateno, 2 Hiroyuki Tadokoro, 3 Jeff Kershaw, 1 Tohru Minamino, 2 Toshiaki Irie, 1 Toshimitsu Fukumura, 1 Issei Komuro, 2 and Tsuneo Saga 1

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Manganese-enhanced magnetic resonance imaging (MEMRI…

There is growing interest in the use of manganese-enhanced MRI (MEMRI) to detect neuronal activity and architecture in animal models. The MEMRI neuronal activity studies have been generally performed either by stereotactic brain injection or by systemic administration of Mn2+ in conjunction with the disruption of the blood–brain barrier (BBB).

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Applications of Manganese-Enhanced Magnetic Resonance Imaging …

In vivo, trans-synaptic tract-tracing utilizing manganese-enhanced magnetic resonance imaging (MEMRI). NMR Biomed. 17 595–601. 10.1002/nbm.942 [Google Scholar] Pautler R. G., Silva A. C., Koretsky A. P. (1998). In vivo neuronal tract tracing using manganese-enhanced magnetic resonance imaging. Magn. Reson.

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In Vivo Evaluation of Neuronal Transport in Murine Models of

In contrast, manganese-enhanced magnetic resonance imaging (commonly termed MEMRI) can provide a noninvasive in vivo assessment of axonal transport at the macroscopic scale. MEMRI is based on two important physico-chemical properties of manganese (Mn 2+).

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Frontiers | Manganese-Enhanced Magnetic Resonance Imaging…

Department of Radiology, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital & Cancer Center, Kunming, China; Manganese-enhanced magnetic resonance imaging (MEMRI) relies on the strong paramagnetism of Mn 2+.Mn 2+ is a calcium ion analog and can enter excitable cells through voltage-gated …

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Neuronal dysfunction of a long projecting multisynaptic

Rationale Manganese (Mn2+)-enhanced magnetic resonance imaging (MEMRI) is an emerging in vivo MR approach for pharmacological research. One new application of MEMRI in this area is to characterize functional changes of a specific neural circuit that is essential to the central effects of a drug challenge. Objectives To develop …

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Manganese-enhanced magnetic resonance imaging (MEMRI)

This special issue of NMR in Biomedicine on manganese-enhanced MRI (MEMRI) is aimed at providing the readers of this journal with an extensive review of some of the most prominent applications of MEMRI in biological systems. Written by several of the leaders in the field, the reviews and original research articles featured in this special …

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Development of a Dendritic Manganese-Enhanced Magnetic Resonance

A new dendritic manganese(II) chelate 1 has been evaluated by in vivo (relaxivity) and in vitro (toxicity and relaxivity) experiments as a manganese enhanced magnetic resonance imaging (MEMRI ...

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Manganese‐enhanced magnetic resonance imaging (MEMRI)

Request PDF | Manganese‐enhanced magnetic resonance imaging (MEMRI) | Manganese ion (Mn2+) is an essential metal that participates as a cofactor in a number of critical biological functions ...

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Studying Axonal Transport in the Brain by Manganese-Enhanced Magnetic

Magnetic resonance imaging (MRI)Magnetic resonance imaging (MRI) provides a non-destructive approach to peer into opaque tissues like the brain. The paramagnetic ion, manganese (MnII), gives a hyperintense signal in T 1 weighted MRIMagnetic resonance imaging (MRI) that can serve as a marker for axonal transportAxonal transport (at).

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Applications of manganese-enhanced magnetic resonance imaging (MEMRI

Manganese-enhanced magnetic resonance imaging (MEMRI) relies on contrasts that are due to the shortening of the T 1 relaxation time of tissue water protons that become exposed to paramagnetic ...

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Manganese-enhanced magnetic resonance imaging (MEMRI)

This special issue of NMR in Biomedicine on manganese-enhanced MRI (MEMRI) is aimed at providing the readers of this journal with an extensive review of some of the most …

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In vivo, trans-synaptic tract-tracing utilizing manganese-enhanced

Manganese-enhanced magnetic resonance imaging (MEMRI) ... study showed that Mn 2+ could aid in the visualization of reactive astrogliosis with manganeseenhanced magnetic resonance imaging (MEMRI ...

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